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Engstrom K, Ameer S, Bernaudat L, et al

However, in hepatic GSH-depleted mice, although decreased lipogenesis was observed, we did not observe increased fatty acid oxidation

The study found that the effect of poly(lactic-co-glycolic acid) nanoparticles containing ceramide on SC formation, as determined by the production of keratinization factors, was similar to or higher than that of free ceramide

This data suggests that while lower doses (5-15g) are excellent for maintenance and mild IBS, repairing severe, pathological "leaky gut" may require transient, high-dose interventions under medical supervision to rapidly force the reassembly of tight junction proteins

Farmer et al., 2014

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